GOD

Neuroplasticity - Effectively this is the ability of the brain to change over the life of the subject, you may think your ability is fixed by nature but nuture can change nature somewhat.

There are plenty of articles on this subject, but one statement pretty much sums it up (Straight out of wikipedia)

Bach-y-Rita believed in sensory substitution; if one sense is damaged, your other senses can sometimes take over. He thought skin and its touch receptors could act as a retina (using one sense for another). In order for the brain to interpret tactile information and convert it into visual information, it has to learn something new and adapt to the new signals. The brain's capacity to adapt implied that it possessed plasticity. He thought, “We see with our brains, not with our eyes.”

Obviously from the above paragraph its not hard to see the implications for "enabled" people, with the question being is one sense overly dominant and taking from another, or plasticity between the senses say with visualists using image sensory parts of the brain for problem solving rather than the prefrontal cortex. Anyway, I have digressed...

The issue I have always wondered about is the basis for depression; I see it as akin to puberty, to pregnancy and other events where the body is directing itself towards "change". But what about change in the mind? Is depression the growing pains? Or simply Natures way of a bet both ways by making some portion of the population (1/3 is a number that always seems to come up with evolutionary dice throwing) more aware and introspective leading to inhibition? (Reticence is a natural hedge against over optimism).

Some of the basis for this idea revolves around some of the greatest minds (male ones) having mothers that were effectively clinical depressives, like the analytical mind being pulled towards the melancholic other hemisphere. Depression activating the more creative side but also accentuating the analytical thought processes.